The way I understand it (and my understanding is certainly poor, so I welcome well-supported pushback on it), is that few, if any, components in the food that we in developed countries eat today are actively harmful in themselves (with the caveat outlined below)

The main issue is overconsumption leading to overweight and obesity. Food that’s high in refined sugars and/or saturated fats tend to contribute to this, because it’s palatable and calorie-dense

So in that sense, yes - I believe that as long as your diet is varied enough that you get sufficient intake of all, or at least most, of the essential nutrients, and you don’t eat too much (i.e. in moderation), the ratio of macronutrients doesn’t make a big difference to your health outcome

The crux is that moderation is hard when the food is jam-packed with calories, and it’s so delicious you just want to keep stuffing your face