- high current 5V USB power supply you probably don't have
- HDMI micro port you have like 1 cable for
- PCIe through very fragile ribbon cable + hodgepodge of adapters
- more adapters needed for SSD
- no case, but needs ample airflow
- power input is on the side and sticks out
GPIO is the killer feature, but I'll be honest, 99% of the hardware hacking I do is with microcontrollers much cheaper than a Pi that provide a serial port over USB anyways (and the commonly-confused-for-a-full-pi Pi Pico is pretty great for this)