It takes an adult sense of responsibility to be able to work effectively from home;
You miss some of the human interaction you'd get from working in an office;
Online relationships aren't as strong as real-life relationships;
You have to be mindful of how to correctly deduct living space/utilities for taxes
I've worked from home for a bit now. I quite enjoy no longer having to sit in a car for 2 hours a day. That's 40 hours a week I've gained back.