If it's not a valuable patent then big players won't respect it (cheap to litigate) and who will want to acquire it? You'll just be run over.
But by defensive usage I mean then at least you know someone else isn't going to patent your key stuff. And once you've got funding/get acquired, the patent could be declared as higher value (and additional fees paid/validation done), and then future litigation to anyone who infringed after that date could be for higher amount.