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Comment by marticode | Hacker News Reader

> higher caffeinated coffee intake was significantly associated with lower dementia risk (141 vs 330 cases per 100 000 person-years comparing the fourth [highest] quartile of consumption with the first [lowest] quartile; hazard ratio, 0.82 [95% CI, 0.76 to 0.89])

That's a very big difference.

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Doing lots of cognition heavy tasks also seems to correlate with lower dementia risk; Basicly the premise of "brain workout" apps. Thought I think if you're going to be doing brain exercises, that time would be better spent learning a new langauge or learning math or physics or art.

Incidently, People who study or do a lot of thinking heavy deep work also tend to be coffee addicts. coincidence?

> Incidently, People who study or do a lot of thinking heavy deep work also tend to be coffee addicts. coincidence?

Coffee can be quite expensive, and thinking work that requires a lot of education tends to correlate with higher income, so I wonder if coffee drinking just acted as another wealth indicator.

You can get very, very cheap coffee.

Good coffee can be expensive, I agree with that.

Looking at the chart the difference is even larger. The cohort quartiles have different drinks/day. looking at just the NHS cohort the difference between 0 and 4.5 drinks/day was an incident rate of 354 to 95 per 100k person-years.

I wonder if this translates to other stimulant use like amphetamines.

The positive effect may be negated by hypertension induced by said stimulants, which would then lead to organic dementias.

So a 100% reduction in risk? Or is it 50% reduction in risk.

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