I'd love to use CrashPlan for the bulk of my older projects but I have 350GB data and as I'm from the UK there is no way to seed it. It would take me something like a month to upload all that data.
What's the big deal? Once it's done - it's done. Unless you're on a metered data-plan, I don't see that initial upload as a huge problem assuming you can keep your system alive for the month it takes to perform the initial upload.