I have really just one wish when it comes to syntax: no syntactically significant whitespace. Space, newline, tab, etc. should ALL map to the same exact token. In practice this also means semicolons or something like them are needed as well, to separate expressions/statements. I dislike langs that try to insert semicolons for you, but at least it's better than the alternative.

the way python treats whitespace is a huge design mistake that has probably wasted like a century (if not more) worth of time across all users, on something really trivial.