Alcohol has fucked up more lives than any other drug in my sphere. People who have had their life fucked by drugs has mostly been because of inhumane government intervention.
// Sweden
// Sweden
How many heroin users do you know who manage to only have 1-2 hits a week socially though and hold down a career.
These are:
Alcohol (+the prescription benzo combo) Gambling Sugar
Add to these tobacco if you want. Nicotine on its won as a standalone agent is perhaps no more damaging than caffeine, but is used in a form-factor that really grills one's lungs.
for example - Russian influenced Balkan areas all take drinking of vodka as something super normal.