AFAIK he hooked up with some adult Russian escorts. There as also a bridge player and I think she was an adult at the time. People know about the escorts because he asked for help getting STD drugs from Epstein. Had he put it in his wife's food as intended that could get him into serious trouble at the time. Not a lawyer but I think planning to do it but not doing it, the statutes of limitations would kick in but I'm certainly no expert on such things.
Adultery / extramarital sex is very common these days and I doubt most people would care. Had he put STD drugs in his wife's food might get a different reaction. In my opinion that is nothing compared to some of the things he is accused of doing to many people in Africa but that's a different topic all together and unrelated to Epstein.