I would also mention, just general auto-immune diseases. I would be very worried this could trigger those in people who wouldn't have gotten one otherwise.
What this treatment does is the opposite side of that coin, it mimics cytokines in order to PROMOTE an immune response.
Immune regulation is an area that deserves a lot more research, and there is going to be learning (harm) along the way. An increasing body of science is pointing to autoimmune diseases being triggered by traditional vaccines, which are then treated by the biologics above that increase the likelihood of other disease due to immunosuppression, which can now be treated(?) by a new immunobooster AKA universal vaccine?
My wife has an autoimmune disease. Most all the evidence points towards gut biome but that shit is super complicated. We have very little research into what our gut biome needs to be.