Also, a note to those who make fancy "me+someservice@somedomain.com" addresses: make really sure you are in control and these work. Some services (including mine) will need to E-mail you one day, for example to tell you that your account will be deleted because of inactivity. If you don't receive that E-mail because of your fancy spam defenses, your account will be deleted. I've seen people hurt themselves like this and it makes me sad.
On a constructive note: what works very well is spam filtering using LLMs. We have AI to help us with this problem today. I wrote an LLM despammer tool which processes my inbox via IMAP using a local LLM (for privacy reasons). I see >97% accuracy in my benchmarks on my (very difficult) testing corpus. It's nearly perfect in real life usage. I've tested many local models in the 4-32B range and the top practical choice is gpt-oss:20b (GGUF, I run it from LM Studio, MLX quantizations are worse) — not only does it perform very well, but it's also really fast.