I have a similar issue. I go to Twitter for many things -- work info, to laugh, friends -- and it doesn't work to have everything jammed into one stream.

I would like to see something split the list of accounts I follow into subject-based lists or something so that I can consume with context.

At some point, I think following becomes less important. Ideally Twitter could just show me tweets that I should enjoy. I'm not looking to get every update anyway -- I just want to dip into a stream of info that I'd find both timely and relevant.