My multi-user node.js chatroom (http://ponyplace.ajf.me/) sustains around 60 concurrent users at any given time on a $5/month (not oversold) VPS. It can sustain a lot more than that too (151 at its highest yet after a 4chan raid).
The secret I find is in not letting your web server gobble up your memory. Don't use Apache, for example. I use nginx.