how many therapeutic proteins are there that aren't mabs or ~naturally occurring proteins (insulin, modified insulins, hirudin, cerezyme etc)?
I can think of:
etanercept
I can think of:
etanercept
The largest commercial classes of multi-domain therapeutic proteins include the crispr (and similar) that drive gene therapies, and the chimeric antigen receptors (and similar) that drive cell therapies.
But lead optimization there look different than this page’s efforts.
I guess I imagine one of the highest order obstacle to protein therapeutics to be immunogenicity, which is really hard to design around for a de Novo protein