Winning only 11 primaries, compared to 42 won by the nominee,
is evidence of a regional/minority-factional 'outlier' candidacy. (And even for those wins, Santorum needed the 'anybody but Romney' dynamic: it was far from broad GOP love for Santorum. Though if you're suffering from the out-group bias I mentioned, it might look that way.)
And yes, a major party's Senate candidate can be an 'outlier'.
In the US, the parties don't pick the candidates, voters do through primaries. Only 36% of Missouri Republican primary voters gave Akin a slim plurality in a no-runoff 3-way primary. Two other candidates in that primary, each with a broader base of national Republican support, got a combined 59% of the GOP vote. So Akin is even somewhat of an outlier in his home, conservative Missouri GOP.
An bigger outlier was the 'major party' Democratic Senate candidate in Tennessee, Mark Clayton:
http://www.washingtonpost.com/politics/decision2012/2012s-wo...
Still, Clayton won the primary and got to run as the Democrat, over the protests of the state party, because that's how the system works. A plurality of voters who show up in low-turnout, often unrepresentative primaries pick the candidates, not the parties.
Yes, the GOP has lost a bunch of its moderate candidates, and that's a problem for the GOP and the country. The causes are both internal GOP malfunctions, and the portrayal-biases I've been mentioning from the media and casual poltical observers. (The moderates rarely get their due respect/coverage as equal Republicans, the Republicans don't get due recognition of their internal diversity. So the breadth of the party has decayed compared to the past, before year-round cable-news/internet politi-tainment narrowed and hardened the party identities.)