Yes, espacially exotic tld. I have a ".email" domain name, and I get 2 to 3 instances a year of either rejected forms, or sneakier, just confirmation email that never come until I use a .com address.
MX->A->PTR->A->MX
SPF
DKIM
DMARC
mta-sts - DNS and webpage
Also your IPs must be squeaky bum clean, ideally for several years. DNSSEC might help too. In the UK getting as far as DKIM is usually enough (plus clean IPs, even FTTC connections will work if static).