Cloudflare Workers is a different runtime and has its own toolchain around it. Nub could theoretically support it when executing files (spawn `wrangler dev` instead of `node` if wrangler.toml is detected or something) but really I'm focused on making the Node.js experience as good as possible.

The other pieces of the toolkit could absolutely be used: package manager, script runner, package runner. Works with anything that implements the Node module resolution algorithm (actually Yarn PnP also works out of the box...).