I use NixOS and haven't restarted my machines in years. Always on. There are power outages once in a while but everything is set to restart when power is available so it comes back up.
Also worth flagging if you are only ever switching in new configs Kernel patches, firmware, or updates to systemd won’t apply until next boot.
My system is rebooted sometimes due to power, and while it comes back just fine... there's no need to reboot a computer that works.