Comment by teekert | Hacker News Reader

Comment by teekert | Hacker News Reader

I'm a scientist, (biophysicist). Over time I have become a bioinformatician and a python dev.

I wrote articles and applications, and it always was a struggle. But now I can speed up, make it all go much faster. But I often feel like my mental models can't keep up.

Recently the AI has generated a comprehensive data model (in Django) and I find myself retracing its steps with long discussions and explanations (with/from the LLM) and searching for documentation. With scientific assignments I find myself searching literature on my own, read whole papers as I used to. Checking the LLM constantly but adapting to it and I don't like it, don't like how it steers me, just let me search, let me wander the scientific landscape on my own, let me read the words of the authors with opposing views. Then let me make 20 plots and only use 1, let me wrestle with the data. Let me make wrong visuals that by chance communicate something important about the data.

Because otherwise I feel uncomfortable, I need to understand, that is what I do. I can reason about so many things because my internal world model is comprehensive and mostly correct. That has taken 44 years so far. Hard work from time to time, but I've mostly enjoyed it.

I still don't know what to make of these models, I use them everyday, but sometimes I wonder if I was not just as fast with Stack Overflow, because what I crave is understanding, not "some finished app". Yes, I rarely finish things fully (that's how I feel), but in research I've often been told they like my ability to move very fast and creatively in phase one, the development is left to others anyway...

I crave an understanding of what these tools mean to me exactly. This comment is part of that. HN is part of that.

Perhaps it is true that the faster you can internalize knowledge (thoroughly, there is a quality aspect to it), the faster you are. Maybe I'm getting old and learning new skills is getting tougher. Maybe, as my world model grows I'm becoming a slow thinker, or a slow learner? New stuff has to be evaluated against a lot of knowledge. But when it clicks, it really feels like a click, it feels satisfying. Like when some new knowledge does not just explain the problem at hand, but also a lot of things that still lingered in the back of your mind.

Recently my wife said that my daughter (ill at the time) may have heatstroke, my response was: It looks like it but she also has a hefty fever (hot after being more than 24 hours out of the sun), I can't really imagine the immune system being involved in heat stroke, although it's possible... My mind went out to heat damaged proteins presenting neo-antigens triggering an immune reaction. I also labelled that as unlikely and more dangerous than what we were observing. I like that I can do that (of course I went on to verify these thoughts!). That reasoning, it's not exactly 100's tokens a sec, but I like the process and it has value.

I also recently observed some weirdness in a dataset, I spend 3 days hunting it down. Long story short: I though I understood how genes make transcripts but I was wrong and ended up adding a new transcript to the human reference genome annotation together with the Gencode people. Now I understand my data better and can separate two different transcripts better in my data (a difference important to our research).

Things like that. The LLM doesn't speed that up, not really. I read a part of a book on gene expression and the function of transcription factors and their interaction with promoters, but I also used LLMs, In the end it was the book with the pictures and clear language that communicated the concepts most clearly. It was made for that of course, and I knew I could trust it (it's tiring to assign <100% confidence to LLM answers), although I know a real scientist also does that with books :)

Maybe I, we all (humanity), will really be faster in the future. Maybe when you grow up with these things you can build world models better and faster. Maybe I'm just too stuck in my ways, as my neuro-plasticity degrades over time. Or maybe it doesn't degrade, maybe I just need more evidence before changing my world models, they have been building on a heavy foundation for a while now.

Your comments really resonate with me. I have been trying to square the rapid progress in AI's abilities to generate proofs of unsolved math problems with comments that Terence Tao has made regarding whether or not these (incredibly impressive) models are actually contributing to mathematical progress.

From Tao on Mathstodon on April 27, 2026: "We are transitioning in mathematics from an era of proof scarcity to an era of proof abundance, but our mathematical infrastructure and culture has not yet adapted to this. As mentioned previously, there is now a strong (and growing) impedance mismatch between the three core components of mathematical problem solving: proof generation, proof verification, and proof digestion.... Perhaps surprisingly, this massive acceleration in proof generation has not actually produced significant acceleration in mathematical progress itself (with the possible exception of #1196, in which all three stages are largely carried out at this point, and for which some digested assessment of developments will soon be forthcoming)."[0]

And I guess my question is, will it matter if humans grasp these new discoveries? If the models are capable of incorporating these discoveries and using them to recursively self improve to unlock new discoveries without humans in the loop, then I guess we humans never really need to understand. I find it hard to believe that a machine can understand concepts that we never will, but I can't reason why that couldn't be the case. Something that holds trillions of concepts in its mind at once might be capable of generating a proof to something that we simply aren't capable of understanding. And the machine just tells us, "Listen, if you are too stupid to understand the new laws of physics I am giving you, then simply follow these very explicit instructions on blasting hydrogen with this laser at this angle in this exact magnet conformation, then you will get cold fusion."

I am really struggling with this. I think superintelligence implies that there will be things about the world that the models understand that we won't. And I can't quite articulate why that is depressing. Because we should still get some cool new tech and some life saving drugs.

[0] https://mathstodon.xyz/@tao/116477352332170731

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