Also (shameless plug), if you want to use murmurHash3 in JavaScript: https://github.com/karanlyons/murmurHash3.js
That said, it's being used by real applications in production, so the niche is definitely there, but for anything that needs any level of security you should continue using a secure hash algorithm, of which the unimaginably named SHA family provides a good set of standard algorithms. Using a secure hash every place you need a hashing algorithm unless you know you'll need the extra perf and know you can get away with it is probably a reasonable practice.