It means that you have to use a less strict Content-Security-Policy, which increases your vulnerability to various client-side JS attacks.
>the risk from Hyperscript is not greater than any other JavaScript in the application.
This is not really the case. If all of your client-side code is loaded via <script src="..."> tags from bundles on your server, and you have a CSP that blocks unsafe-eval or unsafe-inline, then you have a pretty good barrier against execution of untrusted code on your page.