None of this is overly important per-se. Your brain doesn't have a specific pattern of arrangements that must be just so to make a human. But as you start changing these little details, the changes will eventually bubble up to create a different "you".
How much different is hard to say, maybe not even enough to be noticeable. This is firmly in "theoretical" territory. But considering how drastically people can change from relatively small strokes, I would hazard that there isn't a huge amount of deviance allowed.
Perhaps it's possible if you can do it finely enough that only single neurons are changing, allowing time to resynapse (or artificially recreating those connections?). Not sure.