There are some things you cannot easily come back from - or at all - later in life eg poor health decisions, bad finances, not having children.
For most people, the common one is heart disease. Plaque buildup is irreversible. No amount of dieting, exercise, or pharmacology will reverse damage to your arteries. All you can do is prevent further damage, and yes, you will need drugs.
Yeah, I guess this was more my point, you don't ultimately control that much about your health (is my perspective at least), you either win the genetic lottery or not, play the hand you're dealt, enjoy life while it last, in the way you can, some of us can only enjoy it so much compared to the rest of you.