So explain "If we are talking about genes, the goal is to keep the ability to duplicate itself"

That is your basis for 'mistake', and the general position that you are objectively right.

I am saying divergence from the norm can also be a benefit towards the goal of keeping the ability to duplicate. Therefore you can't say that the genetic imperative to duplicate proves you are objectively right. Therefore you can't really support the view that it is a "genetic mistake", unless you want to make the claim that everything thatmakes us different from our proto 1 celled ancestors is a "genetic mistake".