This was a descriptive, not a prescriptive statement, of a real problem. He literally says that it is concerning that prosecuting large institutions can cause economic harm. He isn't saying they won't prosecute, he says it's difficult because of the downsides. Holder made a mistake of wheeling out a complex nuance to a public that isn't prepared to handle it.
I don't understand where is the evidence of malicious force trying to self-serve? Anything specific that points to corruption here? Is this like "yay, Holder gave us a loophole! We just need to build an incredibly large, successful business, and now it will be difficult for Holder to prosecute us, so we can finally start being corrupt"? Is that what you're saying?
What large successful business would want to squander it all on corruption on an off chance that the economic inconvenience would save them from prosecution? They are the most incentivized to identify and remove that sort of PR and legal cancer from their org.