If they have a systemD-less version I'd seriously consider using it.
See also: https://forum.qubes-os.org/t/ultra-minimal-systemd-free-qube...
https://forum.qubes-os.org/t/alpine-linux-template-non-offic...
https://forum.qubes-os.org/t/systemd-inclusion-in-qubesos/22...
The AdminVM is based on Fedora and has systemd, but it has no network and you you shouldn't run anything there. Unless you think that systemd is actively malicious and specifically targets Qubes, any vulnerabilities in it are not exploitable.