it would be awesome if there was an ISA bus emulation using some sort of modern protocol. You could create "modern" ISA cards using an RP2350 on every card that does the emulation, to split emulation between multiple RP2350's (one emulates a VGA card, one emulates a sound card, one emulates a network card, etc.)

Bonus points for a standardized connector that everyone could develop towards. Imagine a tiny ISA PC that you could place on your desktop, swap miniscule (ISA)-cards in and out of, and play retro games etc.