The main thing to watch out for is blocking the rendering or event loop. I've definitely seen apps where a slow API call blocks everything else. So less about performance and more about knowing how to do concurrency well.
I haven't done any mobile stuff in a while, but there should be enough around to wire the agents up into a good environment, like remote chrome-devtools (with or without the MCP).
pnpm workspaces, makes having multiple packages with internal dependencies (like core and components) easy to manage in the dev workspace