I think the issue in physical work are mainly repeated strain on joints and back. Human body was not built to endure so much repeated strain.
I know 5 people closely that have had long careers in the trades.
They are all physically damaged in ways I am not from sitting at a desk.
What I notice about the trades is that the conversation from the inside is mostly about retirement because the work is not fun the way I find my white collar work to be fun.