as a designer, i wholeheartedly agree with his points on the obsessive strive for pixel perfection. no one cares besides designers. or at least no non-designer i've ever asked.

it's becoming a problem. look at dribbble. countless designers would be more likely to obsess over a single misaligned pixel rather than focusing on far more impactful improvements to the user experience.

a pixel perfect button in the wrong spot will always perform worse than a misaligned button in the right spot.