Somehow I don't believe that Cloudflare doubling down on their own runtime -workerd, which will be likely migrated to Rust soon [1]- is the right choice (since it push on semantics that can only be run on Cloudflare infrastructure). I strongly believe Node.js semantics are likely the right ones for agents.
If anyone is looking for a full-open source alternative to Node.js that can run everywhere (browsers, phones or servers), please be aware that you can rely and use Edge.js [2] (disclaimer: Edge.js is part of the company that I founded: Wasmer)