Yeah I tried to daily drive Nix at one point pre AI and the ergonomics were just not a good match for me - perhaps I should try it again.
Then all of my dotfiles are backed up, with any important other config, in a big gig repo. And all of my documents/photos/etc live on a separate hard drive which gets backed up to the cloud.
All of that to say, with the right setup nix is mostly unnecessary, and honestly the benefit of not using it is that I can wipe my system anytime and restart it with just my usual important programs ready to go. Any mess made along the way gets purged automatically in every fresh install