Even for very small n you can create Turing machines where it's incredibly hard to prove that they halt: for n=25 you can create a Turing machine that stops only if the Goldbach conjecture is false.
Though that isn't enough to prove it's not computable, the point stands that if you could compute BB(n) for arbitrary n, you could run a Turing machine for BB(n)+1 steps and if it hasn't stopped yet then you know that the input corresponds to a machine that never halts. So it's impossible to write a program that computes BB(n) for arbitrary n, because doing so is equivalent to the halting problem.
And worse, there are some Turing machines where "proving the Turing machine stops" means "proving that a given set of axioms is consistent", where Gödel's incompleteness theorem says that it's impossible to build such a proof. So, that is how there is some n after which the busy beaver number is defined, but is not computable at all.