(Or "spice" might be synthesized. In Herbert's day (the 1960s) organic chemistry wasn't up to synthesizing arbitrary small-molecule drugs, but now it is. It's a service you can order on line, even. Biologicals take more work, but that's what genetic engineering is for.)
The "mental powers" in Dune aren't that impressive. Compare, say, the Harry Potter universe. In Dune, mentats can convince people. Bene Gesserit can look up stuff in their genetic past. Some people can multitask. There are apps for that.
Herbert wanted knife fighters to matter in battle. Not going to happen. Militaries teach knife fighting to build aggression and for desperate situations, but nobody's battle plan depends on a knife fight. Needs too much surprise. Marines say that their K-Bar knife is useful for everything but combat. Knife fighters, even with force shields, would be vulnerable to riot control weapons, from tear gas to guns that throw sticky nets. Or to being run over and buried by tanks with bulldozer blades, which the US used in the Gulf War. Herbert wrote before a big, modern, desert war.
So the Butlerian Jihad exists only in a plot-armored world specifically designed to make it work.