Agents invalidate a lot of that and so it is an existential threat to many of them. I expect the near future will result in a lot of different results tailored to agents that may actually result in higher priced products for agents browsing versus humans.
If I have to drive to the store to get it, I wouldn’t have shopped with them! It feels like every time I don’t order with Amazon the stores remind me why I ought to.
Walmart is the only other company that can compete at that scale given their very mature ground distribution network and even then Amazon has them beat good on air cargo (Amazon has a virtual cargo airline operated by Air Transport/Atlas Air, both of whom they have some ownership over) and inventory management (they hired some very very smart folks to help them build inventory forecasting systems)
As long as Amazon remains the only company that you can buy almost anything and get it in two or three days almost anywhere on Earth, they won't need to worry about the grim reaper coming for them.
Even if they could, it will be a _long_ time before the average person uses an agent for personal tasks like this
Now whether you want to restrict your shop to only being accessed via a mobile app is a totally different proposition.