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This isn't happening for me, if by "over time" you mean "several weeks" of heavy GPU use without a reboot. Consider the possibility that the root cause is not macOS.

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By "over time" I mean that if I run local LLMs or play graphics-intensive games (like No Man's Sky's native Mac port) I can start seeing up to half-second (or longer) delays in switching apps, starting videos and much more with less than 5 days of uptime. Heavy enough usage will reproduce it within a few hours.

If I avoid doing those things, it can last much longer.

I have the 128GB/8TB M4 Max and I'm not even coming close to using up all or even most of the unified memory. I suspect it may be related to some form of fragmentation, though I have no way to know how.

I believe you, just suggesting that the issue may not be quite as general. I have a 64GB Studio M1 Max, so the years of hardware/firmware differences between us may be relevant as well. Hope you find a solution!

It didn't happen to me before the update, so I suspect it must be something about the update or how it interacts with the software on my system. Still, it's one of those issues I have no hope of seeing solved, because at this rate nobody doing development at Apple is actually going to leave a Mac running for days on end...

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