I think particularly in the case of investors it's that they're pretty comfortable with founders that straddle the fine line between bullish and bullshit, because the ones who back up their claims that seem too good to be true make them money, and the ones who don't are priced in. And some who make them lots of money tell a lot of "white lies" on the way. FOMO is a way of missing red flags too.

Holmes' mistake was to massively overdo the "fake it til you make it" in a regulated industry where the implications of the lies appal people, as well as to have a product that was never going to work so the lies were more "this car definitely isn't just rolling down the hill" than "the person at the wheel is only for regulatory reasons". If she'd settled for fantasy metrics and self dealing in a real estate play rather than faking medical tests she'd have investors lining up to fund her second venture...

I'm more intrigued by how she managed to keep customers and at least some of her employees believing and how often that mask slipped.