ccTLDs are at the whim of the country. If you went with the '.su' ccTLD from the soviet union some years back, well, that would have been quite unfortunate.
Legally I feel like they're also worse. Like, say you're an abortion clinic operating in the regressive country of the US, and you get a '.us' ccTLD, surely it's more likely the government outlaws abortions and censors your domain via the registrar than if you used a '.com'?