Quadcopters that are designed for 45 min to 1 hr loiter time carrying a useful payload, while not being too big for a person to move around seem to be converting on 15 to 18 inch size prop and motor and esc combinations carefully chosen for optimal grams/watt thrust.
I've built a whole slew of drones over the last couple of years, quadcopters are hard to beat on many axis. But I have some proof that it may be possible to do substantially better with a monocopter in terms of efficiency. The hard problems you will then have to solve are payload attachment because unbalance is very tricky to deal with (whereas that is trivial in a quadcopter) as well as transitioning to level flight so that you can make good forward speed.
And what can be learned from full-scale classical helicopters that frequently carry underhanging payloads?
(I don't at all wanna be the typical HN person who thinks their questions about a field they know nothing about are in any way insightful. I'm just trying to learn.)
For a fixed payload it is indeed possible to set up the balance beforehand, even then you will probably end up with a drone that will translate slower or faster depending on the inbalance instead of hovering in place.
https://www.google.com/search?client=firefox-b-d&q=darpa+lif...