A huge number of people just click accept to any popup they get because they're so fed up with seeing them. It's something that is often analysed in design of medical products
It was really difficult to explain to Korea that the additional warnings they wanted me to put in front of the tool operators were actually causing more harm than good. The cultural divide made this really difficult to approach.
"What do you mean the American mfg staff don't actually read everything?!"
"Yeah... Especially at the ATX line. We kind of go off vague shapes around here"
You can put a very clear warning symbol front and centre, and people will just mentally gloss over it