Willing to bet that a default "treat PDFs/documents/spreadsheets as dumb" option in operating systems would eliminate the majority of common one-click vulnerabilies out there. And exactly 0.001% of actual use cases would be affected.
One neat thing I've seen is a PDF that will ping an IP catcher when opened in Adobe, regardless of the security level. The same can be done with word docs, excel spreadsheets, and even SVGs.
Then just have a button for turning those on as needed on a case by case basis