It's a great question. AI guided results of theoretical calculations are already a given (e.g., see https://www.anthropic.com/research/vibe-physics). Right now, I use LLM's as a book-smart colleague, who can explain standard things that I might be weak or unclear about (I am an experimental condensed matter person, so my high-energy and general relativity knowledge isn't very deep.)

I do sort of worry that an experimentalist like me will become more or less a technician in the next decade or so, with AI suggesting experiments, and doing the calculations and data analysis.

But that said, in physics (and particularly biophysics) there are many things that are simply going to have to be done in the real world. Even the action of the simplest enzymes are pretty much beyond our ability to compute from first principles; and any engineered thing that goes into a living system has to be tested, as there are many pathways that are just unknown. I don't care how "smart" an LLM is, it doesn't know what it doesn't know, just like us monkeys.

Over the years I have seen many beautiful theories murdered by ugly experimental facts. AI isn't going to change this.