> Python is harder to JIT because of the way __dict__ works.

Heh, how about how `__class__` works? Not that I recommend actually doing this, but you can literally change the type of an already instantiated object by reassigning `__class__`:

    >>> class Dog:
    ...     def hi(self):
    ...             print("woof")
    ...
    >>> class Cat:
    ...     def hi(self):
    ...             print("meow")
    ...
    >>> dog = Dog()
    >>> dog.hi()
    woof
    >>> dog.__class__ = Cat
    >>> dog.hi()
    meow
    >>> isinstance(dog, Dog)
    False
    >>> isinstance(dog, Cat)
    True
    >>>