> drug sponsorship effect
> activates and drives to the nucleus TFEB, upstream regulator of autophaggy/lysosomal genesis
> trehalose. I wonder if the long half life
> proteins like TFEB are usually conserved
> Activated ... then auto regulated into an off state
This is exactly what I mean by "fairy tales" and nobody really cares how/if/why the drugs work. The blithering word salad of tech jargon above means nothing to a "patient" who is suffering clinical depression. They call these "mood disorders", yet mood is something that is quite ill-defined. It is not a biochemical process. Mood is not something like digestion or pregnancy that can be empirically measured, observed, and described by physicians.
"Mood disorders" are the result of a feminization of mankind. The chief psychological symptom of menstruation is said to be "a bad mood" just before the flow arrives. Rather than address this bad mood in patient-centric terms, women are blamed and singled-out for being fertile or "hysterical", and the bad mood is seen as an obstacle and a detrimental effect. If a woman is having "bad moods" that aren't synchronized with the menstrual period, or heaven forbid, a man has "bad moods", then this must also be a "chemical imbalance" that can be addressed by the writers of fairy-tales and the manufacturers of bizarre, mysterious, but patentable substances.
Mood has nothing to do with this bullshit collection of conjectures. Nobody cares about the mechanism, and it is basically inventing a story to explain something that is immeasurable and unobservable in these terms. It is peak pseudoscience; phrenology and homeopathy are better rooted in reality than psychiatric pharmacology.
It is, ultimately, a bizarre mockery of Christianity, the priesthood, and sacraments. Since hospitals, medical treatment, and the vocation of physician were given their start in a Christian context, as well as the spiritual treatment of the soul. It stood to reason that eventually, they would cross the streams. That they would essentially photocopy the white coats, the prescription pads, the sterile clinics, the scientific diagnostics, and the mysterious substances, and apply them to a system that purports to heal the individual's soul.
Sadly, the mind and spirit do not always respond in the same way that a physical body responds to this sort of treatment. The real Achilles Hell is that spiritual maladies are never individualistic or limited to one unique human being. Mental health treatments are more akin to the Department of Corrections, and operate on a "Divide and Conquer" strategy that seeks to sort people into pigeonholes that are progressively smaller and smaller, dividing us and preventing us from any meaningful unity or communion.