I think the take home here is that there is no such thing as complete isolation in virtualization on modern and complex architectures.
Run them in a data center in a faraday cage under a mountain.
There's so many possibilities that this type of thing will never be solved by invisible (to the agent) boundaries. The sandbox is just another layer in w/e problem you've given it to solve.
There is no such thing as isolation. We’re all connected. Even air gap conducts information in multiple ways, most famously used by humans evolved to use air vibrations to communicate. Photons and other subatomic particles already connects distant stars. We used those electrons and photons to create the modern telecommunications infrastructure. Just an additional layer of connectedness, but not the only one.