IgE disruptor for food allergy with Claude-enabled antibody design [pdf]
divergencelabs.com
divergencelabs.com
If we could tweak our bodies we wouldn’t want to eliminate IgE. But we’d want to have it produced only when a recognizer complex finds thar be worms.
No, not more likely. Possible, but not evidenced, particularly for the allergies IgE causes.
There is a massive profit and political incentive driving this research. It isn’t finding any signals as clear as the real doctors.
> it's just foolish coping IMO
I trust you believe this.
> There's way too much shit in our environment
Sure. And it’s probably harmful. But it doesn’t cause everything.
Cigarettes cause cancer. Cigarettes are bad. That doesn’t mean the asteroid that killed the dinosaurs was caused by cigarettes, and anyone saying that makes no sense is a tobacco shill.
> our resilience is suffering
Suffering resilience is a weird way to describe allergies.
What? What are you even talking about? There's no way to control for exposures to hundreds of thousands of new chemicals in our environment and foods. LITERALLY NO WAY TO CONTROL. Did you know air pollution contributes?
What real doctors are you talking about? You are going up some branch where it's not even misaligned with what I'm talking about you just clearly aren't deep in this subject at all.
"> There's way too much shit in our environment
Sure. And it’s probably harmful. But it doesn’t cause everything.
Cigarettes cause cancer. Cigarettes are bad. That doesn’t mean the asteroid that killed the dinosaurs was caused by cigarettes, and anyone saying that makes no sense is a tobacco shill."
Okay The Plant Slant.
"> our resilience is suffering
Suffering resilience is a weird way to describe allergies."
1.) Not talking about just allergies here 2.) You clearly do not know much about allergies. Do you know anything about the gut microbiome or intestinal lining and how things in our environment, medications, and in our foods contributes to affecting it and those associations with the development and alteration of allergies?
Waiting eagerly for your reply where you just copy-pasted my reply to an LLM to get a synopsis and add your own personal snark to it.
The massive alternate media and medicine market selling supplement and shibboleth around rejecting evidence-based medicine for miasmas.
> LITERALLY NO WAY TO CONTROL. Did you know air pollution contributes?
Yes, we famously have no idea how pollutants affect our health.
> You clearly do not know much about allergies
And you’ve clearly put as much thought into this evaluation as your other comments.
I grew up with severe allergies. They’re now basically treated, apart from spot treatment required when I bust through a patch of grass seed on a hike.
> Not talking about just allergies here
You’re specifically not talking about allergies. A “robust” immune system causes allergies. A childhood bereft of exposure to allergens causes allergies. There is no resilience to antigen under-exposure.
And yes, we can control for PM2.5 and many other pollutants that don’t disperse homogenously into the atmosphere. As can we for various food-borne pollutants. (We can also put other animals in entirely contrived atmospheres, and we do. Then we try the other hypotheses. The evidence speaks to in explanatory path into which pollutants play a role, but not the commanding one.)
I was being punchy. “The pathway of B cell differentiation with respect to the nature and location of potential IgE+ memory cells as well as long-lived IgE producing plasma cells in allergy is still not completely understood” [1]. We do know, however, that “IgE is continuously produced to maintain constant IgE levels in blood,” and that Th2 cells can increase that baseline.
So must be environment that they are brought up in?
Me too, and this statement is just ridiculous.
“When Jasper Lawrence learned that hookworms might lessen the effects of his allergies, he set out on a unique mission: To travel to West Africa and purposefully become infected with the parasite” [1].
[1] https://www.thisamericanlife.org/404/enemy-camp-2010/act-thr...
We adapted by having more children, with the understanding that many wouldn't make it
Would you prefer to live like this? In this more brutish world
Not much fun being the one naturally selected out.
And it's not like evolution don't apply to us anymore, we just have more agency now
All of this being used in practice might be more than 50 years away but there is no biological reason why it should be impossible. Just a lot of work, too much for any single company or government. It will take global coordination, massive investments and maybe the end of capitalism but I think we can pull it off as a civilization.
Early progress on accelerating drug development with Claude
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It's very funny, because IIRC, there's interesting prior art here. Doing this with Rosetta has been a thing for a while now, https://docs.rosettacommons.org/docs/latest/application_docu... https://docs.rosettacommons.org/docs/latest/getting_started/...
I remember hearing about people who wanted to use it to help make vaccines for Zika because there's antibody dependent enhancement there... Not sure what happened.
But the Rosetta project is refreshingly open, https://rosettacommons.org/about/ as entities like OpenAI were meant to be when they first started. There's no gatekeeping here. Do you want to learn how to design an antibody? Here's how you begin, https://www.youtube.com/watch?v=89bQALrPoN0 here's a google colab notebook for it, https://colab.research.google.com/drive/1avuqX7sCjVWX3maOibB...
Google Colab let's you just do it... Starting at $10, https://colab.research.google.com/signup you can access really great GPUs for compute and design antibodies (that will almost certainly never work) to your heart's content. Because that's how it should be.
Science and mathematics work because the results are shared. And most importantly, null results, tools, and frameworks are shared. If these tools are to be used to accelerate science, then they need to be accessible and shared. Even if it's at a high sticker price (assuming that they're costly).
Gating access is a net negative for humanity and our scientific progress. It's also very pointless.
Or preload the context with sufficient clean information, say 500k tokens worth. The guardrails will then trigger less frequently.
It might be that. Might not be. This technology is 50 years old. A nation state has to be filled with people who've never cracked open a physics book if they need a LLM to how to thermonuclear.
If another material, then it's most likely you're looking for FOGBANK. https://en.wikipedia.org/wiki/Fogbank
It's "just" physics at the end of the day. Matter has known properties. Smart people have been able to design these weapons from scratch in 2X to 3X months for over half a century now.