IMHO, although Marxism has some good insights, it's a very limited analysis of reality due to the necessity of framing things within a Hegelian framework, while at the same time ignoring, for example, the most recent peer-reviewed, reproducible discoveries in psychology and neuropsychology. That lack of the later causes all manners of misalignment when real people, and the whole psychological spectrum they comprise, have to intersect with that framework and its implications.

There are some kinda-ish modern, more nuanced versions of Marxism that may be more successful than orthodox variants in that. The Frankfurt School had some quite interesting developments there, such as incorporating Freudian psychology through Lacan, but that is itself already very dated by decades. Also, its approach requires abandoning or inverting many premises of orthodox Marxism, such as, for example, by accepting that in many cases it's the superstructure that determines the infrastructure, not the other way around, so they exist in a tensional relation, which leads adepts of orthodox Marxism to call Frankfurtians revisionists and not to want to hear much more.

So I suppose a fully modernized Marxism incorporating everything modern human sciences has to offer could do reasonably well, but it'd be extremely different from both old school Marxism, as well as from the Frankfurtian revisions.