Ivan Sutherland's Sketchpad (1963) [1] greatly antedates Lisp Machines (but not Lisp!) and is still the best model imnsho for CAD.
[1] https://en.wikipedia.org/wiki/Sketchpad
I'm less sure about this chronology but I think the Evans & Sutherland CAD systems were some of the first examples of multiple graphics coordinate systems that were the progenitor of overlapping windows and the desktop metaphor.