Only in the trivial cases where the compiler already knows that. Data used inside a single function can already be rearranged. Data that is used across more than one function can be rearranged only in the case where the compiler can prove the function is only used in the one translations unit (that is files). If data is used across translations units, there is no way for the compiler to talk with the compiler of the other translations unit to agree on the data rearrangement.

There is some effort in whole program optimization which can solve the above problem in theory. However I don't know how well it works in practice.