Having said that, there would also be the cumulative effects of low/no gravity on astronauts. Even a year on the ISS has profound negative effects on the human body. And humans have cumulatively spent less than a month total on the moon. We have no idea how astronauts would fare on Mars for 18 months, but it would likely be very bad. And then they'd have to successfully get home.
You also have abundant toxic chemicals in the Mars regolith. Whatever technology we'd use to extract drinking water from it would have to filter out perchlorates, which are extremely toxic to both mammal and plant life. AFAIK we've never done this at all on Mars, and now we're talking about having to do it successfully for 18 months (even with water recycling). Not easy!
To be fair, a lot of proponents of human Mars exploration -- particularly here on HN -- see astronauts as essentially disposable. "Who cares if they risk dying of cancer / poisoning / suicide? It's worth it!" But if you prioritize astronauts surviving both the mission to Mars and the return home there are many, many, many unanswered questions, questions which may indeed have no good answers at all.
Before you accuse me of being a hater: I fully support exploration of Mars, and the rest of the solar system. And the best way to do so, by cost and every other conceivable metric, is with robots. Lets spend way more on space exploration, do it with probes of all varieties, and learn more in our lifetime than in all previous human lifetimes put together!